Core tip: The gut microbiota acts as a real organ and many changes in its composition have been reported in colorectal cancer. The pro-carcinogenic properties of bacteria are now better understood. In this review, we discuss possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on the dysbiosis-causing and pro-carcinogenic properties …
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Consulte Mais informaçãoHowever, the clinical trials, based on IDO inhibition, have failed in phase III (ECHO-301/KN-252), probably due to the existence of other pathways generating AhR ligands such as IL4I1. Moreover, it is clear nowadays that several cancer cells are able to produce AhR ligands to activate their own AhR ( Figure 3, Intracrine (Intra)).
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